Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outline
Trial Contact Information
Registry Information

Alternate Title

Neoadjuvant Chemoradiotherapy Followed By Surgery in Treating Patients With Limited-Stage Small Cell Lung Cancer

Basic Trial Information

Phase Type Status Age Sponsor Protocol IDs Phase I Treatment Closed 18 and over NCI FCCC-02613 NCT00062322

Objectives

1. Determine the safety and feasibility of neoadjuvant chemoradiotherapy with irinotecan and cisplatin followed by surgery in patients with limited stage small cell lung cancer.
2. Determine the pathologic complete response rate of patients treated with this regimen.
3. Correlate the level of vascular endothelial growth factor with treatment response and disease outcome in patients treated with this regimen.
4. Correlate genetic polymorphisms in cytochrome P450 1A1, glutathione S-transferase M1 and P1, myeloperoxidase, and NAD(p)H: quinone oxidoreductase with treatment response and disease outcome in patients treated with this regimen.

Entry Criteria

Disease Characteristics:

• Histologically or cytologically confirmed small cell lung cancer
  • Limited stage disease (clinical stage I-IIIA) and meets the following criteria:
    • Confined to 1 hemithorax
    • No T4 disease based on malignant pleural effusion
    • No N3 disease based on contralateral hilar or supraclavicular involvement
  • Contralateral mediastinal (N3) nodes greater than 1.5 cm on CT scan must be biopsied to rule out pathologic involvement



• Measurable or evaluable disease



• Tumor must be able to be encompassed by limited radiotherapy field without significantly compromising pulmonary function



• No pleural effusion visible on chest x-ray (regardless of cytology)



• No prior complete tumor resection

Prior/Concurrent Therapy:

Biologic therapy

• Not specified

Chemotherapy

• No prior irinotecan
• No prior topotecan

Endocrine therapy

• Not specified

Radiotherapy

• No prior radiotherapy to the chest or other areas containing 30% or more of marrow-bearing bone

Surgery

• See Disease Characteristics

Other

• No concurrent phenytoin, phenobarbital, or other antiepileptic prophylactic drugs
• No concurrent amifostine

Patient Characteristics:

Age

• 18 and over

Performance status

• Karnofsky 70-100%

Life expectancy

• Not specified

Hematopoietic

• Absolute granulocyte count at least 1,800/mm³
• Platelet count at least 100,000/mm³

Hepatic

• Bilirubin no greater than 1.5 mg/dL
• No known Gilbert's disease

Renal

• Creatinine no greater than 1.5 mg/dL
• Calcium less than 12.0 mg/dL

Cardiovascular

• No myocardial infarction within the past 6 months
• No congestive heart failure
• No uncontrolled arrhythmias
• No active unstable angina

Pulmonary

• Calculated postoperative FEV₁ at least 800 cc
• No chronic obstructive pulmonary disease with FEV₁ no greater than 1 L or uncontrolled bronchospasm in the unaffected lung

Other

• Not pregnant
• Negative pregnancy test
• Fertile patients must use effective contraception
• No other malignancy within the past 2 years except curatively treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or any other noninvasive malignancy
• No history of seizures
• No history of uncontrolled psychiatric illness that would preclude giving informed consent or complying with study
• No active or uncontrolled infection
• No uncontrolled diabetes mellitus (random blood sugar at least 250 mg/dL)
• No other concurrent serious medical illness
• HIV negative

Expected Enrollment

A total of 20 patients will be accrued for this study.

Outline

This is a pilot study.

• Induction chemotherapy: Patients receive cisplatin IV over 1 hour on day 1 and irinotecan IV over 90 minutes on days 1 and 8.



• Chemoradiotherapy: Beginning on day 21, patients receive chemoradiotherapy comprising radiotherapy once daily, 5 days a week for 4 weeks and then twice daily for 4 days. Patients also receive cisplatin IV and irinotecan IV over 30-60 minutes once weekly concurrently with radiotherapy. Treatment continues in the absence of disease progression or unacceptable toxicity.

  At the completion of chemoradiotherapy, patients are evaluated for surgery. Patients who are candidates for surgery receive one additional course of cisplatin IV and irinotecan IV. Patients who are not candidates for surgery receive radiotherapy twice daily for 4 days and cisplatin IV and irinotecan IV as in chemoradiotherapy.




• Surgery: Approximately 2-4 weeks after the last dose of chemotherapy, patients undergo surgery.

Patients are followed every 4 months for 2 years and then every 6 months for 3 years.

Trial Contact Information

Trial Lead Organizations

Fox Chase Cancer Center - Philadelphia

Steven Feigenberg, MD, Protocol chair		Ph: 215-728-3022; 888-369-2427

Registry Information
Official Title		Phase I Study of Preoperative Chemo/Radiation (Concurrent Irinotecan/Cisplatin/RT) Followed by Surgery in Limited Stage Small Cell Lung Cancer (SCLC-LS)
Trial Start Date		2003-02-12
Registered in ClinicalTrials.gov		NCT00062322
Date Submitted to PDQ		2003-05-06
Information Last Verified		2006-02-11
NCI Grant/Contract Number		P30-CA06927

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