Table 5. MEN Syndromes with Associated Clinical and Genetic Alterations
| Syndrome | Clinical Features/Tumors | Genetic Alterations | |
| MEN type 1: Werner syndrome [2] | Parathyroid | 11q13 (MEN1 gene) | |
| Pancreatic islets: | Gastrinoma | 11q13 (MEN1 gene) | |
| Insulinoma | |||
| Glucagonoma | |||
| VIPoma | |||
| Pituitary: | Prolactinoma | 11q13 (MEN1 gene) | |
| Somatotrophinoma | |||
| Corticotropinoma | |||
| Other associated tumors: | Carcinoid: bronchial and thymic | 11q13 (MEN1 gene) | |
| Adrenocortical | |||
| Lipoma | |||
| MEN type 2A: Sipple syndrome | Medullary thyroid carcinoma | 10q11.2 (RET gene) | |
| Pheochromocytoma | |||
| Parathyroid gland | |||
| MEN type 2B | Medullary thyroid carcinoma | 10q11.2 (RET gene) | |
| Pheochromocytoma | |||
| Mucosal neuromas | |||
| Intestinal ganglioneuromatosis | |||
| Marfanoid habitus | |||
| Familial medullary thyroid carcinoma | Medullary thyroid carcinoma | 10q11.2 (RET gene) | |
References
- Thakker RV: Multiple endocrine neoplasia--syndromes of the twentieth century. J Clin Endocrinol Metab 83 (8): 2617-20, 1998. [PUBMED Abstract]
