Table 3. Common Genetic Syndromes Associated With Adenomatous Polyposis
| Syndrome | Gene | Gene Function | Hereditary Pattern |
| Attenuated familial adenomatous polyposis | APC (5’ mutations), AXIN2 | Tumor suppressor | Dominant |
| Familial adenomatous polyposis (Gardner syndrome) | APC | Tumor suppressor | Dominant |
| Lynch syndrome (hereditary nonpolyposis colorectal cancer) | MSH2, MLH1, MSH6, PMS2, EPCAM | Repair/stability | Dominant |
| Li-Fraumeni syndrome | TP53 (p53) | Tumor suppressor | Dominant |
| MYH-associated polyposis | MYH (MUTYH) | Repair/stability | Recessive |
| Turcot syndrome | APC | Tumor suppressor | Dominant |
| MLH1 | Repair/stability | Dominant |
