Table 4. Anatomic Stage/Prognostic Groupsa,b
| Stage | T | N | M | Dukesc | MACc |
| 0 | Tis | N0 | M0 | -- | -- |
| I | T1 | N0 | M0 | A | A |
| T2 | N0 | M0 | A | B1 |
| IIA | T3 | N0 | M0 | B | B2 |
| IIB | T4a | N0 | M0 | B | B2 |
| IIC | T4b | N0 | M0 | B | B3 |
| IIIA | T1–T2 | N1/N1c | M0 | C | C1 |
| T1 | N2a | M0 | C | C1 |
| IIIB | T3–T4a | N1/N1c | M0 | C | C2 |
| T2–T3 | N2a | M0 | C | C1/C2 |
| T1–T2 | N2b | M0 | C | C1 |
| IIIC | T4a | N2a | M0 | C | C2 |
| T3–T4a | N2b | M0 | C | C2 |
| T4b | N1–N2 | M0 | C | C3 |
| IVA | Any T | Any N | M1a | -- | -- |
| IVB | Any T | Any N | M1b | -- | -- |
| aReprinted with permission from AJCC: Colon and rectum. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 143-164. |
| bcTNM is the clinical classification, and pTNM is the pathologic classification. The y prefix is used for those cancers that are classified after neoadjuvant pretreatment (e.g., ypTNM). Patients who have a complete pathologic response (ypT0, N0, cM0) may be similar to stage group 0 or I. The r prefix is to be used for those cancers that have recurred after a disease-free interval (rTNM). |
| cDukes B is a composite of better (T3, N0, M0) and worse (T4, N0, M0) prognostic groups, as is Dukes C (any T, N1, M0 and any T, N2, M0). MAC is the modified Astler-Coller classification. |
