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National Cancer Institute

at the National Institutes of Health

Melanoma Treatment (PDQ®)

Updated: 05/16/2013

Table 4. Anatomic Stage/Prognostic Groups^a

Stage	T	N	M	Stage	T	N	M
Clinical Staging^b				Pathologic Staging^c
0	Tis	N0	M0	0	Tis	N0	M0
IA	T1a	N0	M0	IA	T1a	N0	M0
IB	T1b	N0	M0	IB	T1b	N0	M0
IB	T2a	N0	M0		T2a	N0	M0
IIA	T2b	N0	M0	IIA	T2b	N0	M0
IIA	T3a	N0	M0		T3a	N0	M0
IIB	T3b	N0	M0	IIB	T3b	N0	M0
IIB	T4a	N0	M0		T4a	N0	M0
IIC	T4b	N0	M0	IIC	T4b	N0	M0
III	Any T	≥N1	M0	IIIA	T1–4a	N1a	M0
III	Any T	≥N1	M0	IIIA	T1–4a	N2a	M0
				IIIB	T1–4b	N1a	M0
					T1–4b	N2a	M0
					T1–4a	N1b	M0
					T1–4a	N2b	M0
					T1–4a	N2c	M0
				IIIC	T1–4b	N1b	M0
					T1–4b	N2b	M0
					T1–4b	N2c	M0
					Any T	N3	M0
IV	Any T	Any N	M1	IV	Any T	Any N	M1

^aReprinted with permission from AJCC: Melanoma of the skin. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 325-44.
^bClinical staging includes microstaging of the primary melanoma and clinical and/or radiologic evaluation for metastases. By convention, it should be used after complete excision of the primary melanoma with clinical assessment for regional and distant metastases.
^cPathologic staging includes microstaging of the primary melanoma and pathologic information about the regional lymph nodes after partial or complete lymphadenectomy. Pathologic Stage 0 or Stage IA patients are the exception; they do not require pathologic evaluation of their lymph nodes.

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