Treatment Options for LCH in Adults
Langerhans cell histiocytosis (LCH) in adults is a lot like LCH in children and can form in the same organs and systems as it does in children. These include the endocrine and central nervous systems, liver, spleen, bone marrow, and gastrointestinal tract. In adults, LCH is most commonly found in the lung as single-system disease. LCH in the lung occurs more often in young adults who smoke. Adult LCH is also commonly found in bone or skin.
In adults, there is not a lot of information about what treatment works best. Sometimes, information comes only from reports of the diagnosis, treatment, and follow-up of one adult or a small group of adults who were given the same type of treatment.Treatment Options for LCH of the Lung
- Quitting smoking for all patients who smoke. Lung damage will get worse over time in patients who do not quit smoking. In patients who quit smoking, lung damage may get better or it may get worse over time.
- Steroid therapy.
- Lung transplant for patients with severe lung damage.
Sometimes LCH of the lung will go away or not get worse even if it's not treated.Treatment Options for LCH of the Bone
Treatment for LCH that affects only the bone in adults may include:Treatment Options for LCH of the Skin
Treatment for LCH that affects only the skin in adults may include:
- Steroid therapy applied to the skin.
- Photodynamic therapy with psoralen and ultraviolet A radiation (PUVA).
- Chemotherapy or biologic therapy given by mouth, such as methotrexate, thalidomide, or interferon.
- Retinoid therapy may be used if the skin lesions do not get better with other treatment.
Treatment for LCH that affects the skin and other body systems may include:
Treatment of single-system and multisystem disease in adults may include:
- Chemotherapy. A drug that makes the immune system less active may also be used.
- Bisphosphonate therapy.
- Targeted therapy with imatinib mesylate.
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with adult Langerhans cell histiocytosis. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.