Treatment Options for Ewing Sarcoma

Localized Ewing Sarcoma
Metastatic Ewing Sarcoma
Recurrent Ewing Sarcoma

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your child's doctor for clinical trials that are not listed here but may be right for your child.

The treatment of localized Ewing sarcoma always includes chemotherapy. Surgery, radiation therapy, or both may also be used. The treatments and the order they are given in depends on the following:

• Where in the body the tumor started.
• The size of the tumor.
• Whether the treatment will affect the way the child will look or important body functions.

See the Treatment Option Overview section of this summary for more information about surgery, chemotherapy, and radiation therapy used to treat children with Ewing sarcoma. New ways of giving combination chemotherapy are being studied for localized Ewing sarcoma.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with localized Ewing sarcoma/peripheral primitive neuroectodermal tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

The treatment of metastatic Ewing sarcoma always includes chemotherapy. Surgery, radiation therapy, or both may also be used. The treatments and the order they are given depends on the following:

• Where in the body the tumor started.
• Where the tumor has spread.
• The size of the tumor.
• Whether the treatment will affect the way the child will look or important body functions.

See the Treatment Option Overview section of this summary for more information about surgery, chemotherapy, and radiation therapy used to treat children with Ewing sarcoma. Chemotherapy followed by radiation therapy or stem cell transplant is being studied for Ewing sarcoma that has spread to the lung only.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with metastatic Ewing sarcoma/peripheral primitive neuroectodermal tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Treatment of recurrent Ewing sarcoma may include the following:

• Combination chemotherapy.
• Surgery to remove bone tumors.
• Radiation therapy to bone tumors, as palliative therapy to reduce symptoms and improve the quality of life.
• Radiation therapy followed by surgery to remove tumors that have spread to the lungs.
• A clinical trial of targeted therapy with a monoclonal antibody.
• A clinical trial of new combinations of drugs and targeted therapy.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent Ewing sarcoma/peripheral primitive neuroectodermal tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.