Table 5. Radiation Therapy (RT) Dose According to Rhabdomyosarcoma Group, Histology, and Site of Disease (Children's Oncology Group [COG])
| Group | Treatment |
| Group I | |
| Embryonal | No RT. |
| Alveolar | 36 Gy to involved (prechemotherapy) site. The use of RT is under investigation. |
| Group II | |
| N0 (microscopic residual disease after surgery) | 36 Gy to involved (prechemotherapy) site. |
| N1 (resected regional lymph node involvement) | 41.4 Gy to involved (prechemotherapy) site and nodes. |
| Group III | |
| Orbital and nonorbital tumors | 50.4 Gy with volume reduction after 36 Gy if excellent response to chemotherapy and noninvasive pushing tumors; no volume reduction for invasive tumors. |
| Group IV | |
| As for other groups and including all metastatic sites, if safe and possible. Exception: lung (pulmonary metastases) treated with 15 Gy if aged 6 years or older, 12 Gy if younger than 6 years. | |
