Table 2. Acute Leukemias of Ambiguous Lineage According to the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissuesa
| Condition | Definition |
| Acute undifferentiated leukemia | Acute leukemia that does not express any marker considered specific for either lymphoid or myeloid lineage |
| Mixed phenotype acute leukemia with t(9;22)(q34;q11.2); BCR-ABL1 | Acute leukemia meeting the diagnostic criteria for mixed phenotype acute leukemia in which the blasts also have the (9;22) translocation or the BCR-ABL1 rearrangement |
| Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged | Acute leukemia meeting the diagnostic criteria for mixed phenotype acute leukemia in which the blasts also have a translocation involving the MLL gene |
| Mixed phenotype acute leukemia, B/myeloid, NOS | Acute leukemia meeting the diagnostic criteria for assignment to both B and myeloid lineage, in which the blasts lack genetic abnormalities involving BCR-ABL1 or MLL |
| Mixed phenotype acute leukemia, T/myeloid, NOS | Acute leukemia meeting the diagnostic criteria for assignment to both T and myeloid lineage, in which the blasts lack genetic abnormalities involving BCR-ABL1 or MLL |
| Mixed phenotype acute leukemia, B/myeloid, NOS—rare types | Acute leukemia meeting the diagnostic criteria for assignment to both B- and T-lineage |
| Other ambiguous lineage leukemias | Natural killer cell lymphoblastic leukemia/lymphoma |
| NOS = not otherwise specified; WHO = World Health Organization. | |
| aBéné MC: Biphenotypic, bilineal, ambiguous or mixed lineage: strange leukemias! Haematologica 94 (7): 891-3, 2009. [24] Obtained from Haematologica/the Hematology Journal website http://www.haematologica.org. |
References
- Béné MC: Biphenotypic, bilineal, ambiguous or mixed lineage: strange leukemias! Haematologica 94 (7): 891-3, 2009. [PUBMED Abstract]
