Table 2. CNS-Directed Treatment Regimens for Newly Diagnosed Childhood ALL
| Disease Status | Standard Treatment Options | |
| ALL = acute lymphoblastic leukemia; CNS = central nervous system; CNS3 = cerebrospinal fluid with 5 or more white blood cells/µL and cytospin positive for blasts. | ||
| Standard-risk ALL | Intrathecal chemotherapy | |
| Methotrexate alone | ||
| Methotrexate with cytarabine and hydrocortisone | ||
| CNS-penetrant systemic chemotherapy | ||
| Dexamethasone | ||
| L-asparaginase | ||
| High-dose methotrexate with leucovorin rescue | ||
| High-risk ALL | Intrathecal chemotherapy | |
| Methotrexate alone | ||
| Methotrexate with cytarabine and hydrocortisone | ||
| CNS-penetrant systemic chemotherapy | ||
| Dexamethasone | ||
| L-asparaginase | ||
| High-dose methotrexate with leucovorin rescue | ||
| Cranial radiation | ||
