Table 1. Historical Classification Systems for NHL
| Working Formulation [3] | Rappaport Classification |
| Low grade | |
| A. Small lymphocytic, consistent with chronic lymphocytic leukemia | Diffuse lymphocytic, well-differentiated |
| B. Follicular, predominantly small-cleaved cell | Nodular lymphocytic, poorly differentiated |
| C. Follicular, mixed small-cleaved, and large cell | Nodular mixed, lymphocytic, and histiocytic |
| Intermediate grade | |
| D. Follicular, predominantly large cell | Nodular histiocytic |
| E. Diffuse, small-cleaved cell | Diffuse lymphocytic, poorly differentiated |
| F. Diffuse mixed, small and large cell | Diffuse mixed, lymphocytic, and histiocytic |
| G. Diffuse, large cell, cleaved, or noncleaved cell | Diffuse histiocytic |
| High grade | |
| H. Immunoblastic, large cell | Diffuse histiocytic |
| I. Lymphoblastic, convoluted, or nonconvoluted cell | Diffuse lymphoblastic |
| J. Small noncleaved-cell, Burkitt, or non-Burkitt | Diffuse undifferentiated Burkitt or non-Burkitt |
References
- National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: summary and description of a working formulation for clinical usage. The Non-Hodgkin's Lymphoma Pathologic Classification Project. Cancer 49 (10): 2112-35, 1982. [PUBMED Abstract]
