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Genetics of Prostate Cancer (PDQ®)

  • Posted: 11/20/2003
  • Updated: 02/15/2013

Table 9. Prostate Cancer Susceptibility Loci Identified Through GWAS

Nearest Known Gene Within 100 kb Chromosomal Locus SNP Region Study Citations ORa 
GGCX 2p11rs10187424Intergenic[174]1.06–1.19
EHBP1 2p15rs721048Intronic[177]1.15
THADA 2p21rs1465618Intronic[178]1.16–1.20
ITGA6 2q31rs12621278Intronic[178]1.32 –1.47
MLPH 2q37rs2292884Intronic[179]1.14
VGLL3 3p12rs2660753Intergenic[180]1.11–1.48
EEFSEC 3q21rs10934853Intronic[116]1.12
ZBTB38 3q23rs6763931Intronic[179]1.04–1.18
CLDN11 3q26rs10936632Intergenic[174]1.08–1.28
PDLIM5 4q22rs12500426Intronic[178]1.14–1.17
PDLIM5 4q22rs17021918Intronic[178]1.12–1.25
TET2 4q24rs7679673Intergenic[178]1.15–1.37
FGF10 5p12rs2121875Intronic[174]1.05–1.11
TERT 5p15rs2242652Intronic[179]1.15–1.39
CCHCR1 6p21rs130067Exonic/Coding[179]1.05–1.20
SLC22A3 6q25rs9364554Intronic[180]1.17–1.26
JAZF1 7p15rs10486567Intronic[181]1.12–1.35
LMTK2 7q21rs6465657Intronic[180]1.03–1.19
SLC25A37 8p21rs2928679Intergenic[178]1.16–1.26
NKX3-1 8p21rs1512268Intergenic[178]1.13–1.28
None8q24rs10086908Intergenic[86]1.14–1.25
None8q24rs7841060Intergenic[85]1.19
None8q24rs13254738Intergenic[74]1.11
None8q24rs16901979Intergenic[73]1.66
None8q24rs16902094Intergenic[116]1.21
None8q24rs445114Intergenic[116]1.14
None8q24rs620861Intergenic[85,86]1.11–1.28
None8q24rs6983267Intergenic[72,74,86,181]1.13–1.42
None8q24rs7000448Intergenic[74]1.14
None8q24rs1447295Intergenic[67,72,73]1.29–1.72
MSMB 10q11rs10993994Intergenic[180]1.15–1.42
CTBP2 10q26rs4962416Intronic[181]1.17–1.20
TH 11p15rs7127900Intergenic[178]1.29–1.40
MYEOV 11q13rs11228565Intergenic[116]1.23
MYEOV 11q13rs7931342Intergenic[180]1.19–1.25
MYEOV 11q13rs10896449Intergenic[182]1.09–1.20
MYEOV 11q13rs12793759Intergenic[182]1.04–1.18
MYEOV 11q13rs10896438Intergenic[182]1.02–1.12
KRT8 12q13rs902774Intergenic[179]1.17
TUBA1C 12q13rs10875943Intergenic[174]1.02–1.18
HNF1B 17q12rs11649743Intronic[183]1.28
HNF1B 17q12rs4430796Intronic[101,183]1.16–1.38
None17q24rs1859962Intergenic[101]1.20
PPP1R14A 19q13rs8102476Intergenic[116]1.12
KLK3 19q13rs2735839Intergenic[180]1.25–1.72
BIK 22q13rs5759167Intergenic[178]1.14–1.20
NUDT11 Xp11rs5945619Intergenic[180]1.19–1.46
AR Xq12rs5919432Intergenic[179]1.06–1.14

GWAS = genome-wide association studies; kb = kilobase; OR = odds ratio.
aORs are reported as a range across the various stages of GWAS discovery and validation when available.

References

  1. Amundadottir LT, Sulem P, Gudmundsson J, et al.: A common variant associated with prostate cancer in European and African populations. Nat Genet 38 (6): 652-8, 2006.  [PUBMED Abstract]

  2. Yeager M, Orr N, Hayes RB, et al.: Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet 39 (5): 645-9, 2007.  [PUBMED Abstract]

  3. Gudmundsson J, Sulem P, Manolescu A, et al.: Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet 39 (5): 631-7, 2007.  [PUBMED Abstract]

  4. Haiman CA, Patterson N, Freedman ML, et al.: Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet 39 (5): 638-44, 2007.  [PUBMED Abstract]

  5. Yeager M, Chatterjee N, Ciampa J, et al.: Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nat Genet 41 (10): 1055-7, 2009.  [PUBMED Abstract]

  6. Al Olama AA, Kote-Jarai Z, Giles GG, et al.: Multiple loci on 8q24 associated with prostate cancer susceptibility. Nat Genet 41 (10): 1058-60, 2009.  [PUBMED Abstract]

  7. Gudmundsson J, Sulem P, Steinthorsdottir V, et al.: Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet 39 (8): 977-83, 2007.  [PUBMED Abstract]

  8. Gudmundsson J, Sulem P, Gudbjartsson DF, et al.: Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Nat Genet 41 (10): 1122-6, 2009.  [PUBMED Abstract]

  9. Kote-Jarai Z, Olama AA, Giles GG, et al.: Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat Genet 43 (8): 785-91, 2011.  [PUBMED Abstract]

  10. Gudmundsson J, Sulem P, Rafnar T, et al.: Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet 40 (3): 281-3, 2008.  [PUBMED Abstract]

  11. Eeles RA, Kote-Jarai Z, Al Olama AA, et al.: Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet 41 (10): 1116-21, 2009.  [PUBMED Abstract]

  12. Schumacher FR, Berndt SI, Siddiq A, et al.: Genome-wide association study identifies new prostate cancer susceptibility loci. Hum Mol Genet 20 (19): 3867-75, 2011.  [PUBMED Abstract]

  13. Eeles RA, Kote-Jarai Z, Giles GG, et al.: Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet 40 (3): 316-21, 2008.  [PUBMED Abstract]

  14. Thomas G, Jacobs KB, Yeager M, et al.: Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet 40 (3): 310-5, 2008.  [PUBMED Abstract]

  15. Chung CC, Ciampa J, Yeager M, et al.: Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer. Hum Mol Genet 20 (14): 2869-78, 2011.  [PUBMED Abstract]

  16. Sun J, Zheng SL, Wiklund F, et al.: Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nat Genet 40 (10): 1153-5, 2008.  [PUBMED Abstract]