Table 12. Summary of Cross-Sectional Studies of Anticipated Interest in Prostate Cancer Susceptibility Genetic Testing
| Study Population | Sample Size | Percent Expressing Interest in Genetic Testing | Other Findings |
| FDR = first-degree relative; PSA = prostate-specific antigen | |||
| Prostate screening clinic participants [17] | 342 men aged 40–97 y | 89% | 28% did not demonstrate an understanding of the concept of inherited predisposition to cancer. |
| General population; 9% with positive family history [8] | 12 focus groups with a total of 90 men aged 18–70 y | All focus groups | |
| African American men [18] | 320 men aged 21–98 y | 87% | Most participants could not distinguish between genetic susceptibility testing and a prostate-specific antigen blood test. |
| Men with and without FDRs with prostate cancer [9] | 126 men >40 y; mean age 52.6 y | 24% definitely; 50% probably | |
| Swedish men with an FDR with prostate cancer [3] | 110 men aged 40–72 y | 76% definitely; 18% probably | 89% definitely or probably wanted their sons to undergo genetic testing. |
| Sons of Swedish men with prostate cancer [10] | 101 men aged 21–65 y | 90%; 100% of sons with two or three family members affected with prostate cancer | 60% expressed worry about having an increased risk of prostate cancer. |
| Healthy outpatient males with no history of prostate cancer [19] | 400 men aged 40–69 y | 82% | |
| Healthy African American males with no history of prostate cancer [20] | 413 African American men aged 40–70 y | 87% | Belief in the efficacy of and intention to undergo prostate cancer screening was associated with testing interest. |
| Healthy Australian males with no history of prostate cancer [21] | 473 adult men | 66% definitely; 26% probably | 73% reported that they felt diet could influence prostate cancer risk. |
| Males with prostate cancer and their unaffected male family members [22] | 559 men with prostate cancer; 370 unaffected male relatives | 45% of men affected with cancer; 56% of unaffected men | In affected men, younger age and test familiarity were predictors of genetic testing interest. In unaffected men, older age, test familiarity, and a PSA test within the last 5 y were predictors of genetic testing interest. |
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