Table 1. Estimated Relative and Absolute Risk of Developing Colorectal Cancer (CRC)
| Family History | Relative Risk of CRC [44] | Absolute Risk (%) of CRC by Age 79 ya |
| No family history | 1 | 4a |
| One first-degree relative with CRC | 2.3 (95% CI, 2.0–2.5) | 9b |
| More than one first-degree relative with CRC | 4.3 (95% CI, 3.0–6.1) | 16b |
| One affected first-degree relative diagnosed with CRC before age 45 y | 3.9 (95% CI, 2.4–6.2) | 15b |
| One first-degree relative with colorectal adenoma | 2.0 (95% CI, 1.6–2.6) | 8b |
| CI = confidence interval. | ||
| aData from the Surveillance, Epidemiology, and End Results database. | ||
| bThe absolute risks of CRC for individuals with affected relatives was calculated using the relative risks for CRC [44] and the absolute risk of CRC by age 79 yearsa. |
References
- Johns LE, Houlston RS: A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol 96 (10): 2992-3003, 2001. [PUBMED Abstract]
