Table 9. High-probability Ovarian Cancer Susceptibility Loci Identified Through Genome-Wide Association Studies
| Putative Gene(s) | Chromosome | SNP | Study Citation | Odds Ratio (95% Confidence Interval) | Comment |
| SNP = single nucleotide polymorphism. | |||||
| HOXD1 | 2q31.1 | rs2072590 | [131] | 1.16 (1.12–1.21) | Stronger in serous cancers |
| TIPARP | 3q25.31 | rs2665390 | [131] | 1.19 (1.11–1.27) | |
| Intergenic/MYC, THEM75 | 8q24.21 | rs10088218 | [131] | 0.84 (0.80–0.89) | |
| BNC2 | 9p22.2 | rs3814113 | [132] | 0.82 (0.79–0.86) | Stronger in serous cancers; also in BRCA1 and BRCA2 [133] |
| SKAP1 | 17q21.32 | rs9303542 | [131] | 1.11 (1.06–1.16) | |
| BABAM1 | 19p13.11 | rs8170 | [134] | 1.18 (1.12–1.25) | Serous cancers only |
| ANKLE1 | 19p13.11 | rs2363956 | [134] | 1.16 (1.11–1.21) | |
References
- Goode EL, Chenevix-Trench G, Song H, et al.: A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet 42 (10): 874-9, 2010. [PUBMED Abstract]
- Song H, Ramus SJ, Tyrer J, et al.: A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet 41 (9): 996-1000, 2009. [PUBMED Abstract]
- Ramus SJ, Kartsonaki C, Gayther SA, et al.: Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst 103 (2): 105-16, 2011. [PUBMED Abstract]
- Bolton KL, Tyrer J, Song H, et al.: Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet 42 (10): 880-4, 2010. [PUBMED Abstract]
