Table 3. Estimated Cumulative Breast and Ovarian Cancer Risks in BRCA1 and BRCA2 Mutation Carriers
| Study | Breast cancer risk (%) by age 70 y (95% CI) | Ovarian cancer risk (%) by age 70 y (95% CI) | ||
| CI = confidence interval. | ||||
| BRCA1 | BRCA2 | BRCA1 | BRCA2 | |
| Antoniou et al. [110] | 65 (44–78) | 45 (31–56) | 39 (18–54) | 11 (2.4–19) |
| Chen et al. [111] | 55 (50–59) | 47 (42–51) | 39 (34–45) | 17 (13–21) |
References
- Antoniou A, Pharoah PD, Narod S, et al.: Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72 (5): 1117-30, 2003. [PUBMED Abstract]
- Chen S, Parmigiani G: Meta-analysis of BRCA1 and BRCA2 penetrance. J Clin Oncol 25 (11): 1329-33, 2007. [PUBMED Abstract]
