Adjuvant Treatment of Rectal Cancer
Name of the Trial
Why This Trial Is Important
To help prevent recurrence and improve survival, doctors are exploring the use of other treatments given either before (neoadjuvant) or after (adjuvant) surgery. In this trial, patients who were treated previously with neoadjuvant chemoradiotherapy (chemotherapy combined with radiation therapy) will be randomly assigned to receive adjuvant chemotherapy with or without the addition of the monoclonal antibody bevacizumab, which inhibits tumor blood vessel formation. Researchers will compare the overall survival of patients in the two treatment groups.
This trial is designed to accommodate patients who received neoadjuvant chemoradiotherapy as part of another clinical trial conducted by the National Surgical Adjuvant Breast and Bowel Project (NSABP-R-04).
"These two trials are intended to help define the best way to administer neoadjuvant and adjuvant treatment for rectal cancer," said Dr. Benson. "We hope to extend the benefits we have seen recently in adjuvant treatment for colon cancer to patients with rectal cancer."
Who Can Join This Trial
Study Sites and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.