Treatment for Metastatic Ocular Melanoma
Name of the Trial
Why This Trial Is Important
In this trial, researchers are testing a new drug called lenalidomide (Revlimid) to see if it can stop or slow the growth of ocular melanoma metastases and help patients live longer. Researchers will compare two different doses of the drug to assess its antitumor activity and possible side effects. Lenalidomide is thought to inhibit the growth of new blood vessels to tumors (a process called angiogenesis), thereby restricting the supply of nutrients needed for tumor growth. It may also possess other antitumor activities, such as stimulating the immune system and promoting tumor cell apoptosis (suicide).
"Lenalidomide is a novel antiangiogenic agent that we hope can help shrink tumors in patients with metastatic ocular melanoma," said Dr. Libutti. "This trial will help us determine whether lenalidomide can produce meaningful inhibition of tumor vasculature and what effects such inhibition has on the growth of these tumors."
Who Can Join This Trial
Study Site and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.