Chemotherapy for Inoperable Liver Metastases from Ocular Melanoma
Name of the Trial
Why is This Trial Important?
In this study, researchers are testing a procedure called hyperthermic isolated hepatic perfusion, which involves temporarily separating the liver's blood supply from the blood circulating throughout the rest of the body. High concentrations of the drug melphalan are then administered to the liver. Once treatment with melphalan is completed, the liver's blood supply is reconnected to the rest of the circulatory system and patients are treated with the drug temozolomide.
"Isolating the liver allows us to deliver a higher dose of melphalan than could be tolerated systemically," said Dr. James Pingpank, a surgeon involved with the trial. "Isolated perfusions have been used to treat cancer in other organs, but this is the first time isolated hepatic perfusion is being used with a large number of patients. The technology just wasn't there before.
"In phase I and II testing, this therapy did produce a response in 62 percent of patients, so it does have established efficacy," said Dr. Pingpank. "Now we are trying to prolong the duration of response, which is currently about 1 year."
Who Can Join This Trial?
Where Is This Trial Taking Place?
Whom to Contact
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